Kind of an obscure topic here, but I just watched the end of the Pittsburgh/San Diego came. Pittsburgh was a 4 point favorite, and they were ahead 11-10 on the last play of the game when San Diego had the ball. Yeah, they would win the game but wouldn't cover the spread.
But on that screwy last play, Pittsburgh returned a fumble and scored a TD. As far as the game is concerned, the touchdown was meaningless. For those betting on Pittsburgh, it meant everything.
Then the officials reviewed the play (and the only reason they did so had to be that millions of dollars were wagered on the game) and took the TD off the board. But I'm not sure why.
In Vegas, there are people still staring at the big screen.
Edit:
Here's a story about it along with video.